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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
基因組-scale metabolic 網絡s are highly robust to the elimination of enzyme-coding genes. Their structure can evolve rapidly through 突變s that eliminate such genes and through horizontal gene transfer that adds new enzyme-coding genes. Using flux balance analysis we study a vast space of metabolic 網絡 genotypes and their relationship to metabolic phenotypes, the ability to sustain life in an environment defined by an available spectrum of carbon sources. Two such 網絡s typically differ in most of their reactions and have few essential reactions in common. Our observations suggest that the robustness of the Escherichia coli metabolic 網絡 to 突變s is typical of 網絡s with the same phenotype. We also demonstrate that 網絡s with the same phenotype form large sets that can be traversed through single 突變s, and
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