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原文連結
論文資訊
- 類型：已發表論文
- 日期：2009
摘要
Despite the rapidly increasing number of sequenced and re- sequenced 基因組s, many issues regarding the 計算 assembly of large-scale sequencing data have remain unresolved. 計算 assembly is crucial in large 基因組 projects as well for the evolving high-throughput technologies and plays an important role in processing the 資訊 generated by these methods. Here, we provide a comprehensive overview of the current publicly available sequence assembly programs. We describe the basic principles of 計算 assembly along with the main concerns, such as repetitive sequences in genomic DNA, highly expressed genes and alternative transcripts in EST sequences. We summarize existing comparisons of different assemblers and provide a detailed descriptions and directions for download of assembly programs at:
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