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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Dynamical changes of RNA secondary structures play an important role in the function of many regulatory RNAs. Such kinetic effects, especially in time-variable and externally triggered systems, are usually investigated by means of extensive and expensive simulations of large sets of individual folding trajectories. Here we describe the theoretical foundations of a generic approach that not only allows the direct computation of approximate 族群 densities but also reduces the efforts required to analyze the folding energy landscapes to a one- time preprocessing step. The basic idea is to consider the kinetics on individual landscapes and to model external triggers and environmental changes as small but discrete changes in the landscapes. A "barmap'' links macrostates of temporally adjacent lan
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