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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Background: As Pandemic (H1N1) 2009 influenza spreads around the globe, it strikes school-age children more often than adults. Although there is some evidence of pre-existing immunity among older adults, this alone may not explain the significant gap in age-specific infection rates. Methods and Findings: Based on a retrospective analysis of pandemic strains of influenza from the last century, we show that school-age children typically experience the highest attack rates in primarily naive 族群s, with the burden shifting to adults during the subsequent season. Using a parsimonious 網絡-based 數學 model which incorporates the changing distribution of contacts in the susceptible 族群, we demonstrate that new pandemic strains of influenza are expected to shift the 流行病學ological landscape in exactly thi
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