摘要 A steady increase in knowledge of the molecular a

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論文資訊

• 類型：已發表論文
• 日期：2010

摘要

A steady increase in knowledge of the molecular and antigenic structure of the gp120 and gp41 HIV-1 envelope glyco蛋白質s (Env) is yielding important new insights for vaccine design, but it has been difficult to translate this 資訊 to an immunogen that elicits broadly neutralizing antibodies. To help bridge this gap, we used 系統發育ally corrected 統計 methods to identify amino acid signature patterns in Envs derived from people who have made potently neutralizing antibodies, with the hypothesis that these Envs may share common features that would be useful for incorporation in a vaccine immunogen. Before attempting this, essentially as a control, we explored the utility of our 計算 methods for defining signatures of complex neutralization phenotypes by analyzing Env sequences from 251 clonal 病毒es that

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