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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Abstract: Background: A practical problem during the analysis of natural 網絡s is their complexity, thus the use of synthetic circuits would allow to unveil the natural mechanisms of operation. Autocatalytic gene regulatory 網絡s play an important role in shaping the development of multicellular organisms, whereas oscillatory circuits are used to control gene expression under variable environments such as the light-dark cycle. Results: We propose a new mechanism to generate developmental patterns and oscillations using a minimal number of genes. For this, we design a synthetic gene circuit with an antagonistic self-regulation to study the spatio-temporal control of 蛋白質 expression. Here, we show that our minimal system can behave as a 生物 clock or memory, and it exhibites an inherent robustness
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