摘要 An effective HIV vaccine must elicit 免疫 responses

本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。

原文連結

• SFI 頁面

論文資訊

• 類型：已發表論文
• 日期：2010

摘要

An effective HIV vaccine must elicit 免疫 responses that recognize 遺傳ally diverse 病毒es(1,2). It must generate CD8(+) T lymphocytes that control HIV replication and CD4(+) T lymphocytes that provide help for the generation and maintenance of both cellular and humoral 免疫 responses against the 病毒(3-5). Creating immunogens that can elicit cellular 免疫 responses against the 遺傳ally varied circulating isolates of HIV presents a key challenge for creating an HIV vaccine(6,7). Polyvalent mosaic immunogens derived by in silico recombination of natural strains of HIV are designed to induce cellular 免疫 responses that recognize 遺傳ally diverse circulating 病毒 isolates(8). Here we immunized rhesus monkeys by plasmid DNA prime and recombinant vaccinia 病毒 boost with vaccine constructs expressing either consens

※ 此為已發表論文，全文需透過期刊付費取得