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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Background: The availability of high density 遺傳 maps and genotyping platforms has transformed human 遺傳 studies. The use of these platforms has enabled 族群-based 基因組-wide association studies. However, in inheritance-based studies, current methods do not take full advantage of the 資訊 present in such genotyping analyses. Results: In this paper we describe an improved method for identifying 遺傳 regions shared identical-by-descent (IBD) from recent common ancestors. This method improves existing methods by taking advantage of phase 資訊 even if it is less than fully accurate or missing. We present an analysis of how using phase 資訊 increases the accuracy of IBD detection compared to using only genotype 資訊. Conclusions: Our algorithm should have utility in a wide range of 遺傳 studies that rely on iden
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