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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Background: The occurrence of a 遺傳 bottleneck in HIV sexual or mother-to-infant 傳播 has been well documented. This results in a majority of new infections being homogeneous, i.e., initiated by a single 遺傳 strain. Early after infection, prior to the onset of the host 免疫 response, the viral 族群 grows exponentially. In this simple setting, an approach for estimating 演化ary and demographic parameters based on comparison of 多樣性 measures is a feasible alternative to the existing 貝氏 methods (e.g., BEAST), which are instead based on the simulation of genealogies. Results: We have devised a web tool that analyzes 遺傳 多樣性 in acutely infected HIV-1 patients by comparing it to a model of neutral growth. More specifically, we consider a homogeneous infection (i.e., initiated by a unique 遺傳 strain) prior to
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