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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Background: The ultimate goal of synthetic biology is the conception and construction of 遺傳 circuits that are reliable with respect to their designed function (e. g. oscillators, switches). This task remains still to be attained due to the inherent synergy of the 生物 building blocks and to an insufficient feedback between experiments and 數學 models. Nevertheless, the progress in these directions has been substantial. Results: It has been emphasized in the literature that the architecture of a 遺傳 oscillator must include positive (activating) and negative (inhibiting) 遺傳 interactions in order to yield robust oscillations. Our results point out that the oscillatory capacity is not only affected by the interaction polarity but by how it is implemented at promoter level. For a chosen oscillator a
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