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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Background: Two genes are called synthetic lethal (SL) if 突變 of either alone is not lethal, but 突變 of both leads to death or a significant decrease in organism's fitness. The detection of SL gene pairs constitutes a promising alternative for anti-癌症 therapy. As 癌症 cells exhibit a large number of 突變s, the identification of these mutated genes' SL partners may provide specific anti-癌症 drug candidates, with minor perturbations to the healthy cells. Since existent SL data is mainly restricted to yeast screenings, the road towards human SL candidates is limited to inference methods. Results: In the present work, we use 系統發育 analysis and database manipulation (BioGRID for interactions, Ensembl and NCBI for homology, Gene Ontology for GO attributes) in order to reconstruct the 系統發育ally-inferred S
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