本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Chromatin regulation is understood to be one of the fundamental modes of gene regulation in eukaryotic cells. We argue that the basic 蛋白質s that determine the chromatin architecture constitute an 演化ary ancient layer of transcriptional regulation common to all three domains of life. We explore 系統發育ally, sources of innovation in chromatin regulation, focusing on 蛋白質 domains related to chromatin structure and function, demonstrating a step-wise increase of complexity in chromatin regulation. Building upon the highly conserved use of variants of chromosomal architectural 蛋白質s to distinguish chromosomal states, Eukarya secondarily acquired mechanisms for "writing" chemical modifications onto chromatin that constitute persistent signals. The acquisition of reader domains enabled decoding of these
※ 此為已發表論文，全文需透過期刊付費取得