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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Elucidating 病毒-host interactions responsible for HIV-1 傳播 is important for advancing HIV-1 prevention strategies. To this end, single 基因組 amplification (SGA) and sequencing of HIV-1 within the context of a model of random 病毒 演化 has made possible for the first time an unambiguous identification of transmitted/founder 病毒es and a precise estimation of their numbers. Here, we applied this approach to HIV-1 env analyses in a cohort of acutely infected men who have sex with men (MSM) and found that a high proportion (10 of 28; 36%) had been productively infected by more than one 病毒. In subjects with multivariant 傳播, the minimum number of transmitted 病毒es ranged from 2 to 10 with viral recombination leading to rapid and extensive 遺傳 shuffling among 病毒 lineages. A combined analysis of these result
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