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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Human apolipo蛋白質 B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G, hereinafter referred to as A3G) is an innate 病毒 restriction factor that inhibits human immunodeficiency 病毒 type 1 (HIV-1) replication and induces excessive deamination of cytidine residues in nascent reverse transcripts. To test the hypothesis that this enzyme can also help generate viral sequence diversification and the 演化 of beneficial viral variants, we have examined the impact of A3G on the acquisition of (-)2',3'-dideoxy-3'-thiacytidine (3TC) resistance in vitro. That characteristic resistance 突變s are rapidly fixed in the presence of A3G and 3TC suggests that A3G-mediated editing can be an important source of 遺傳 variation on which 自然選擇 acts to shape the structure of HIV-1 族群s.
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