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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Induction of antibodies that neutralize a broad range of human immunodeficiency 病毒 type 1 (HIV-1) isolates is a major goal of vaccine development. To study natural examples of broad neutralization, we analyzed sera from 103 HIV-1-infected subjects. Among progressor patients, 20% of sera neutralized more than 75% of a panel of 20 diverse viral isolates. Little activity was observed in sera from long-term nonprogressors (elite controllers). Breadth of neutralization was correlated with viral load, but not with CD4 count, history of past antiretroviral use, age, gender, race/ethnicity, or route of exposure. Clustering analysis of sera by a novel method identified a 統計ly robust subgrouping of sera that demonstrated broad and potent neutralization activity.
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