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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Most studies of 細菌l pathogen 族群s have been based on isolates collected from individuals with 疾病, or their contacts, over short time periods. For commensal organisms that occasionally cause 疾病, such as Neisseria meningitidis, however, the analysis of isolates from long-term asymptomatic carriage is necessary to elucidate their 演化 and 族群 structure. Here, we use 數學 models to analyse the structuring and dynamics of three vaccine-candidate antigens among carried meningococcal isolates collected over nearly 30 years in the Czech Republic. The data indicate that stable combinations of antigenic alleles were maintained over this time period despite evidence for high rates of recombination, consistent with theoretical models in which strong 免疫 selection can maintain non- overlapping combinations of
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