摘要 Motivation: It has been proven that the accessibi

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原文連結

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論文資訊

• 類型：已發表論文
• 日期：2010

摘要

Motivation: It has been proven that the accessibility of the target sites has a critical influence on RNA-RNA binding, in general and the specificity and efficiency of miRNAs and siRNAs, in particular. Recently, O(N-6) time and O(N-4) space dynamic programming (DP) algorithms have become available that compute the partition function of RNA-RNA interaction complexes, thereby providing detailed insights into their 熱力學 properties. Results: Modifications to the grammars underlying earlier approaches enables the calculation of interaction probabilities for any given interval on the target RNA. The computation of the 'hybrid probabilities' is complemented by a 隨機 sampling algorithm that produces a Boltzmann weighted ensemble of RNA-RNA interaction structures. The sampling of k structures require

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