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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
Targeted drugs could significantly reduce cytotoxic effect and increase therapeutic activity. Dihydroartemisinin (DHA) has been shown to be effective in killing 癌症 cells. However, it exhibits non-targeted property. Holo-transferrin (TF) is a suitable drug-carrier to target 癌症 cells, because 癌症 cells need iron uptake by the TF- mediated mechanism to maintain their uncon-trolled growth. Furthermore, TF receptors (TF-R) are highly expressed on 癌症 cell surfaces. In this paper, 3-(4,5-dimethylthi-azol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the different killing effect of 4-(12- Dihydroart-emisininoxy) Benzoic Acid Hydrozide-transferrin (DBAH-TF) on human breast 癌症 cells (MCF-7) cells and human normal breast (HNB) cells, and atomic force microscopy (AFM) was used
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