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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
The current paradigm for modeling viral kinetics and resistance 演化 after treatment initiation considers only the level of circulating 病毒 and cellular infection (Cl model), while the intra- cellular level is disregarded. This model was successfully used to explain HIV dynamics and Hepatitis C 病毒 (HCV) dynamics during interferon-based therapy. However, in the new era of direct-acting antiviral 智能體s (DAAs) against HCV, viral kinetics is characterized by a more rapid decline of the wild-type 病毒 as well as an early 湧現 of resistant strains that jeopardize the treatment outcome. Although the Cl model can be extended to describe these new kinetic patterns, this approach has qualitative and quantitative limitations. Instead, we suggest that a more appropriate approach would consider viral dynamics
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