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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
The organization of 蛋白質 structures in 蛋白質 genotype space is well studied. The same does not hold for 蛋白質 functions, whose organization is important to understand how novel 蛋白質 functions can arise through blind 演化ary searches of sequence space. In systems other than 蛋白質s, two organizational features of genotype space facilitate phenotypic innovation. The first is that genotypes with the same phenotype form vast and connected genotype 網絡s. The second is that different neighborhoods in this space contain different novel phenotypes. We here characterize the organization of enzymatic functions in 蛋白質 genotype space, using a data set of more than 30,000 蛋白質s with known structure and function. We show that different neighborhoods of genotype space contain 蛋白質s with very different functions. This
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