本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
We describe a 數學 model and 蒙地卡羅( MC) simulation of viral 演化 during acute infection. We consider both synchronous and a synchronous processes of viral infection of new target cells. The model enables an assessment of the expected sequence 多樣性 in new HIV-1 infections originating from a single transmitted viral strain, estimation of the most recent common ancestor (MRCA) of the transmitted viral lineage, and estimation of the time to coalesce back to the MRCA. We also calculate the probability of the MRCA being the transmitted 病毒 or an evolved variant. Excluding insertions and deletions, we assume HIV-1 evolves by base substitution without selection pressure during the earliest phase of HIV-1 infection prior to the 免疫 response. Unlike 系統發育 methods that follow a lineage backwards to coalescenc
※ 此為已發表論文，全文需透過期刊付費取得