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原文連結
論文資訊
- 類型：已發表論文
- 日期：2010
摘要
基因組 sequencing of Helicobacter pylori has revealed the potential 蛋白質s and 遺傳 多樣性 of this prevalent human pathogen, yet little is known about its transcriptional organization and noncoding RNA output. Massively parallel cDNA sequencing (RNA-seq) has been r演化izing global transcriptomic analysis. Here, using a novel differential approach (dRNA-seq) selective for the 5' end of primary transcripts, we present a 基因組-wide map of H. pylori transcriptional start sites and operons. We discovered hundreds of transcriptional start sites within operons, and opposite to annotated genes, indicating that complexity of gene expression from the small H. pylori 基因組 is increased by uncoupling of polycistrons and by 基因組-wide antisense transcription. We also discovered an unexpected number of similar to 60 smal
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