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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
Since Bateson's discovery that genes can suppress the phenotypic effects of other genes, gene interactions-called epistasis-have been the topic of a vast research effort. Systems and developmental biologists study epistasis to understand the genotype-phenotype map, whereas 演化ary biologists recognize the fundamental importance of epistasis for 演化. Depending on its form, epistasis may lead to divergence and speciation, provide 演化ary benefits to sex and affect the robustness and evolvability of organisms. That epistasis can itself be shaped by 演化 has only recently been realized. Here, we review the empirical pattern of epistasis, and some of the factors that may affect the form and extent of epistasis. Based on their divergent consequences, we distinguish between interactions with or without
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