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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
Motivation: Currently, the best RNA-RNA interaction prediction tools are based on approaches that consider both the inter-and intramolecular interactions of hybridizing RNAs. While accurate, these methods are too slow and memory-hungry to be employed in 基因組-wide RNA target scans. Alternative methods neglecting intramolecular structures are fast enough for 基因組-wide applications, but are too inaccurate to be of much practical use. Results: A new approach for RNA-RNA interaction was developed, with a prediction accuracy that is similar to that of algorithms that explicitly consider intramolecular structures, but running at least three orders of magnitude faster than RNAup. This is achieved by using a combination of precomputed accessibility profiles with an approximate energy model. This appr
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