摘要 Complex regulation of biochemical pathways in a c

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論文資訊

• 類型：已發表論文
• 日期：2011

摘要

Complex regulation of biochemical pathways in a cell is brought about by the interaction of simpler regulatory structures. Among the basic regulatory designs, feedback inhibition of gene expression is the most common motif in gene regulation and a ubiquitous control structure found in nature. In this work, we have studied a common structural feature (delayed feedback) in gene organisation and shown, both theoretically and experimentally, its subtle but important functional role in gene expression kinetics in a negatively auto-regulated system. Using simple deterministic and 隨機 models with varying levels of realism, we present detailed theoretical representations of negatively auto-regulated transcriptional circuits with increasing delays in the establishment of feedback of repression. The

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