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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
Empirical observations and theoretical studies suggest that 病毒es may use different replication strategies to amplify their 基因組s, which impact the dynamics of 突變 accumulation in viral 族群s and therefore, their fitness and virulence. Similarly, during natural infections, 病毒es replicate and infect cells that are rarely in suspension but spatially organized. Surprisingly, most quasi物種 models of 病毒 replication have ignored these two phenomena. In order to study these two viral characteristics, we have developed 隨機 細胞自動機 models that simulate two different modes of replication (geometric vs stamping machine) for quasi物種 replicating and spreading on a two-dimensional space. Furthermore, we explored these two replication models considering epistatic 適應度景觀s (antagonistic vs synergistic) and different
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