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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
Genes that underlie human 疾病 are important subjects of systems biology research. In the present study, we demonstrate that Mendelian and complex 疾病 genes have distinct and consistent 蛋白質-蛋白質 interaction (PPI) properties. We show that five different 網絡 properties can be reduced to two independent metrics when applied to the human PPI 網絡. These two metrics largely coincide with the degree (number of connections) and the clustering coefficient (the number of connections among the neighbors of a particular 蛋白質). We demonstrate that 疾病 genes have simultaneously unusually high degree and unusually low clustering coefficient. Such genes can be described as brokers in that they connect many 蛋白質s that would not be connected otherwise. We show that these results are robust to the effect of gene age
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