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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
Motivation: The task of reconstructing a genomic sequence from a particular 物種 is gaining more and more importance in the light of the rapid development of high-throughput sequencing technologies and their limitations. Applications include not only compensation for missing data in unsequenced genomic regions and the design of oligonucleotide primers for target genes in 物種 with lacking sequence 資訊 but also the preparation of customized queries for homology searches. Results: We introduce the maxAlike algorithm, which reconstructs a genomic sequence for a specific taxon based on sequence homologs in other 物種. The input is a multiple sequence alignment and a 系統發育 tree that also contains the target 物種. For this target 物種, the algorithm computes nucleotide probabilities at each sequence positio
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