摘要 Mucosal 傳播 of the human immunodeficiency 病毒 (HIV)

本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。

原文連結

• SFI 頁面

論文資訊

• 類型：已發表論文
• 日期：2011

摘要

Mucosal 傳播 of the human immunodeficiency 病毒 (HIV) results in a bottleneck in viral 遺傳 多樣性. Gnanakaran and colleagues used a 計算 strategy to identify signature amino acids at particular positions in Envelope that were associated either with transmitted sequences sampled very early in infection, or sequences sampled during chronic infection. Among the strongest signatures observed was an enrichment for the stable presence of histidine at position 12 at 傳播 and in early infection, and a recurrent loss of histidine at position 12 in chronic infection. This amino acid lies within the leader peptide of Envelope, a region of the 蛋白質 that has been shown to influence envelope glyco蛋白質 expression and virion infectivity. We show a strong association between a positively charged amino acid like histidin

※ 此為已發表論文，全文需透過期刊付費取得