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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
Signaling pathways are interconnected to regulatory circuits for sensing the environment and expressing the appropriate 遺傳 profile. In particular, gradients of diffusing molecules (morphogens) determine cell fate at a given position, dictating development and spatial organization. The feedforward loop (FFL) circuit is among the simplest 遺傳 architectures able to generate one-stripe patterns by operating as an amplitude detection device, where high output levels are achieved at intermediate input ones. Here, using a heuristic optimization-based approach, we dissected the design space containing all possible topologies and parameter values of the FFL circuits. We explored the ability of being sensitive or adaptive to variations in the critical morphogen level where cell fate is switched. We f
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