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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
生物 systems at various levels of organisation exhibit robustness, as well as phenotypic variability or evolvability, the ability to evolve novel phenotypes. We still know very little about the relationship between robustness and phenotypic variability at levels of organisation beyond individual macromolecules, and especially for signalling circuits. Here, we examine multiple alternate topologies of the Saccharomyces cerevisiae target-of-rapamycin (TOR) signalling circuit, in order to understand the circuit's robustness and phenotypic variability. We consider each of the topological variants a genotype, a set of alternative interactions between TOR circuit components. Two genotypes are neighbours in genotype space if they can be reached from each other by a single small 遺傳 change. Each genot
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