摘要 細菌l 基因組s encode a plethora of small RNAs (sRNAs),

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論文資訊

• 類型：已發表論文
• 日期：2011

摘要

細菌l 基因組s encode a plethora of small RNAs (sRNAs), which are heterogeneous in size, structure and function. Most sRNAs act as post-transcriptional regulators by means of specific base pairing interactions with the 5'-untranslated region of mRNA transcripts, thereby modifying the stability of the target transcript and/or its ability to be translated. Here, we present RNA捕食者, a web server for the prediction of sRNA targets. The user can choose from a set of over 2155 基因組s and plasmids from 1183 細菌l 物種. RNA捕食者 then uses a dynamic programming approach, RNAplex, to compute putative targets. Compared to web servers with a similar task, RNA捕食者 takes the accessibility of the target during the target search into account, improving the specificity of the predictions. Furthermore, enrichment in Gene O

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