聖塔非研究所

繞過 RNA 沉默的最佳病毒策略

2011 · 已發表論文 · 更新 2026/08/30 下午12:48

摘要 The RNA silencing pathway constitutes a defence mechanism highly conserved in eukaryotes, especially in plants, where the underlying working principle relies on the repressive action trig…

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論文資訊

  • 類型:已發表論文
  • 日期:2011

摘要

The RNA silencing pathway constitutes a defence mechanism highly conserved in eukaryotes, especially in plants, where the underlying working principle relies on the repressive action triggered by the intracellular presence of double-stranded RNAs. This 免疫 system performs a post-transcriptional suppression of aberrant mRNAs or viral RNAs by small interfering RNAs (siRNAs) that are directed towards their target in a sequence-specific manner. However, 病毒es have evolved strategies to escape from silencing surveillance while promoting their own replication. Several 病毒es encode suppressor 蛋白質s that interact with different elements of the RNA silencing pathway and block it. The different suppressors are not 系統發育ally nor structurally related and also differ in their mechanism of action. Here, we a

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