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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
Recombination hotspots are small chromosomal regions, where meiotic crossover events happen with high frequency. Recombination is initiated by a double-strand break (DSB) that requires the intervention of the molecular repair mechanism. The DSB repair mechanism may result in the exchange of homologous chromosomes (crossover) and the conversion of the allelic sequence that breaks into the one that does not break (biased gene conversion). Biased gene conversion results in a 傳播 advantage for the allele that does not break, thus preventing recombination and rendering recombination hotspots transient. How is it possible that recombination hotspots persist over 演化ary time (maintaining the average chromosomal crossover rate) when they are self-destructive? This fundamental question is known as th
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