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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011
摘要
It is well known that non-enzymatic template directed molecular replicators X + nO -> k 2X exhibit parabolic growth d[X]/dt infinity kX. Here, we analyze the dependence of the effective replication rate constant k on hybridization energies, temperature, strand length, and sequence composition. First we derive analytical criteria for the replication rate k based on simple 熱力學 arguments. Second we present a Brownian dynamics model for oligonucleotides that allows us to simulate their 擴散 and hybridization behavior. The simulation is used to generate and analyze the effect of strand length, temperature, and to some extent sequence composition, on the hybridization rates and the resulting optimal overall rate constant k. Combining the two approaches allows us to semi-analytically depict
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