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論文資訊
- 類型:已發表論文
- 日期:2011-09-07
摘要
We propose and study 非線性 數學 models describing the intracellular time dynamics of viral RNA accumulation for positive-sense single-stranded RNA 病毒es. Our models consider different replication modes ranging between two extremes represented by the geometric replication (GR) and the linear stamping machine replication (SMR). We first analyse a model that quantitatively reproduced experimental data for the accumulation dynamics of both polarities of turnip mosaic poty病毒 RNAs. We identify a non-degenerate transcritical 分岔 governing the extinction of both strands depending on three key parameters: the mode of replication (alpha), the replication rate (r) and the degradation rate (delta) of viral strands. Our results indicate that the 分岔 associated with alpha generically takes place when the repli
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