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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011-11-23
摘要
We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in 族群s of 蛋白質s, in spite of the fact that the phosphorylation-state transitions of any molecule, by means of which the switch is implemented, are highly 隨機. The 湧現 of switching is a nonequilibrium 相變 in an energetically driven, dissipative system described by a master equation. We use operator and functional integral methods from reaction-擴散 theory to solve for the phase structure, noise spectrum, and escape trajectories and first-passage times of a class of minimal models of switches, showing how all critical properties for switch behavior can be computed within a unified framework.
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