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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011-11-24
摘要
Background: Secondary structure forms an important intermediate level of description of nucleic acids that encapsulates the dominating part of the folding energy, is often well conserved in 演化, and is routinely used as a basis to explain experimental findings. Based on carefully measured 熱力學 parameters, exact dynamic programming algorithms can be used to compute ground states, base pairing probabilities, as well as 熱力學 properties. Results: The ViennaRNA Package has been a widely used compilation of RNA secondary structure related computer programs for nearly two decades. Major changes in the structure of the standard energy model, the Turner 2004 parameters, the pervasive use of multi-core CPUs, and an increasing number of algorithmic variants prompted a major technical overhaul of both th
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