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原文連結
論文資訊
- 類型：已發表論文
- 日期：2011-12-22
摘要
Host-pathogen interactions underlie one of the most complex 演化ary phenomena resulting in continual adaptive 遺傳 changes, where pathogens exploit the host's molecular resources for growth and survival, while hosts try to eliminate the pathogen. Deciphering the molecular basis of host–pathogen interactions is useful in understanding the factors governing pathogen 演化 and 疾病 propagation. In host-pathogen context, a balance between 突變, selection, and 遺傳漂變 is known to maintain codon bias in both organisms. Studies revealing determinants of the bias and its dynamics are central to the understanding of host-pathogen 演化. We considered the Human Immunodeficiency 病毒 (HIV) type 1 and its human host to search for 演化ary signatures in the viral 基因組. Positive selection is known to dominate intra-host 演化 of
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