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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
Background: In the laboratory, the Drosophila melanogaster heat shock 蛋白質 Hsp90 can buffer the phenotypic effects of 遺傳 variation. Laboratory experiments either manipulate Hsp90 activity pharmacologically, or they induce 突變s with strong effects in the gene Hsp83, the single-copy fly gene encoding Hsp90. It is unknown whether observations from such laboratory experiments are relevant in the wild. Results: We here study naturally occurring 突變s in Hsp83, and their effects on fitness and phenotypic buffering in flies derived from wild 族群s. We examined more than 4500 flies from 42 Drosophila 族群s distributed world-wide for insertions or deletions of mobile DNA in or near the Hsp83 gene. The insertions we observed occur at low 族群 frequencies, and reduce Hsp83 gene expression. In competition exper
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