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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative studies supported that the overall sign of epistasis switches from positive to negative as the complexity of an organism increases, and it has been hypothesized that this change shall be a consequence of the underlying gene 網絡 properties. Why should this be the case? What characteristics of 遺傳 網絡s determine the sign of epistasis? Here we show, by evolving 遺傳 網絡s that differ in their complexity and robustness against perturbations but that perform the same tasks, that robustness increased with complexity and that epistasis was positive for small nonrobust 網絡s but negative f
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