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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
How epistatic interactions between 突變s determine the 遺傳 architecture of fitness is of central importance in 演化. The study of epistasis is particularly interesting for RNA 病毒es because of their genomic compactness, lack of 遺傳 redundancy, and apparent low complexity. Moreover, interactions between 突變s in viral 基因組s determine traits such as resistance to antiviral drugs, virulence and host range. In this study we generated 53 Tobacco etch poty病毒 genotypes carrying pairs of single-nucleotide substitutions and measured their separated and combined deleterious fitness effects. We found that up to 38% of pairs had significant epistasis for fitness, including both positive and negative deviations from the null hypothesis of multiplicative effects. Interestingly, the sign of epistasis was correlate
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