摘要 In general terms, robustness is the capacity of 生

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論文資訊

• 類型：已發表論文
• 日期：2012

摘要

In general terms, robustness is the capacity of 生物 systems to function in spite of 遺傳 or environmental perturbations. The small and compacted 基因組s and high 突變 rates of RNA 病毒es, as well as the ever-changing environments wherein they replicate, create the conditions for robustness to be advantageous. In this review, I will enumerate possible mechanisms by which viral 族群s may acquire robustness, distinguishing between mechanisms that are inherent to 病毒 replication and 族群 dynamics and those that result from the interaction with host factors. Then, I will move to review some evidences that RNA 病毒 族群s are robust indeed. Finally, I will comment on the implications of robustness for 病毒 evolvability, the 湧現 of new 病毒es and the efficiency of lethal mutagenesis as an antiviral strategy.

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