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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
Motivation: Cytosine DNA methylation is one of the major epi遺傳 modifications and influences gene expression, developmental processes, X-chromosome inactivation, and genomic imprinting. Aberrant methylation is furthermore known to be associated with several 疾病s including 癌症. The gold standard to determine DNA methylation on 基因組-wide scales is 'bisulfite sequencing': DNA fragments are treated with sodium bisulfite resulting in the conversion of unmethylated cytosines into uracils, whereas methylated cytosines remain unchanged. The resulting sequencing reads thus exhibit asymmetric bisulfite-related mismatches and suffer from an effective reduction of the alphabet size in the unmethylated regions, rendering the mapping of bisulfite sequencing reads 計算ly much more demanding. As a consequence,
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