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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
New 蛋白質-coding genes can originate either through modification of existing genes or de novo. Recently, the importance of de novo origination has been recognized in eukaryotes, although eukaryotic genes originated de novo are relatively rare and difficult to identify. In contrast, 病毒es contain many de novo genes, namely those in which an existing gene has been "overprinted" by a new open reading frame, a process that generates a new 蛋白質-coding gene overlapping the ancestral gene. We analyzed the 演化 of 12 experimentally validated viral genes that originated de novo and estimated their relative ages. We found that young de novo genes have a different codon usage from the rest of the 基因組. They evolve rapidly and are under positive or weak purifying selection. Thus, young de novo genes might ha
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