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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
Plant artificial micro-RNAs (amiRs) have been engineered to target viral 基因組s and induce their degradation. However, the exceptional 演化ary plasticity of RNA 病毒es threatens the durability of the resistance conferred by these amiRs. It has recently been shown that viral 族群s not experiencing strong selective pressure from an antiviral amiR may already contain enough 遺傳 variability in the target sequence to escape plant resistance in an almost deterministic manner. Furthermore, it has also been shown that viral 族群s exposed to subinhibitory concentrations of the antiviral amiR speed up this process. In this article, we have characterized the molecular 演化ary dynamics of an amiR target sequence in a viral 基因組 under both conditions. The use of Illumina ultradeep sequencing has allowed us to identi
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