本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
The combinatorial cross-regulation of hundreds of sequence-specific transcription factors (TFs) defines a regulatory 網絡 that underlies cellular identity and function. Here we use 基因組-wide maps of in vivo DNaseI footprints to assemble an extensive core human regulatory 網絡 comprising connections among 475 sequence-specific TFs and to analyze the dynamics of these connections across 41 diverse cell and tissue types. We find that human TF 網絡s are highly cell selective and are driven by cohorts of factors that include regulators with previously unrecognized roles in control of cellular identity. Moreover, we identify many widely expressed factors that impact transcriptional regulatory 網絡s in a cell-selective manner. Strikingly, in spite of their inherent 多樣性, all cell-type regulatory 網絡s indepe
※ 此為已發表論文，全文需透過期刊付費取得