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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
The increase of bodyplan complexity in early bilaterian 演化 is correlates with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two known microRNAs whose origins date back before the bilaterian ancestor is mir-100. In Bilateria, it appears stably associated in polycistronic transcripts with let-7 and mir-125, two key regulators of development. In vertebrates, these three microRNA families have expanded to form a 複雜系統 of developmental regulators. In this contribution, we disentangle the 演化ary history of the let-7 locus, which was restructured independently in nematodes, platyhelminths, and deuterostomes.
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