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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
The molecular mechanisms underlying viral pathogenesis are yet poorly understood owed to the large number of factors involved and the complexity of their interactions. Could we identify a minimal set of host transcription factors (TF) whose misregulation would result in the transcriptional profile characteristic of infected cells in absence of the 病毒? How many of such sets exist? Are all orthogonal or share critical TFs involved in specific 生物 functions? We have developed a 計算 methodology that uses a quantitative model of the transcriptional regulatory 網絡 (TRN) of Arabidopsis thaliana to explore the landscape of all possible re-engineered TRNs whose transcriptomic profiles mimic those observed in infected plants. We found core sets containing between six and 34 TFs, depending on the 病毒, wh
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