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原文連結
論文資訊
- 類型：已發表論文
- 日期：2012
摘要
The relationship between the genotype (sequence) and the phenotype (structure) of macromolecules affects their ability to evolve new structures and functions. We here compare the genotype space organization of 蛋白質s and RNA molecules to identify differences that may affect this ability. To this end, we 計算ly study the genotype-phenotype relationship for short RNA and lattice 蛋白質s of a reduced monomer alphabet size, to make exhaustive analysis and direct comparison of their genotype spaces feasible. We find that many fewer 蛋白質 molecules than RNA molecules fold, but they fold into many more structures than RNA. In consequence, 蛋白質 phenotypes have smaller genotype 網絡s whose member genotypes tend to be more similar than for RNA phenotypes. Neighborhoods in sequence space of a given radius around
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